CacheFX: A Framework for Evaluating Cache Security

Over the last two decades, the danger of sharing resources between programs has been repeatedly highlighted. Multiple side-channel attacks, which seek to exploit shared components for leaking information, have been devised, mostly targeting shared caching components. In response, the research community has proposed multiple cache designs that aim at curbing the source of side channels. With multiple competing designs, there is a need for assessing the level of security against side-channel attacks that each design offers. Several metrics have been suggested for performing such evaluations. However, these tend to be limited both in terms of the potential adversaries they consider and in the applicability of the metric to real-world attacks, as opposed to attack techniques. Moreover, all existing metrics implicitly assume that a single metric can encompass the nuances of side-channel security. In this work we propose CacheFX, a flexible framework for assessing and evaluating the resilience of cache designs to sidechannel attacks. CacheFX allows the evaluator to implement various cache designs, victims, and attackers, as well as to exercise them for assessing the leakage of information via the cache. To demonstrate the power of CacheFX, we implement multiple cache designs and replacement algorithms, and devise three evaluation metrics that measure different aspects of the caches: (1) the entropy induced by a memory access; (2) the complexity of building an eviction set; (3) protection against cryptographic attacks; Our experiments highlight that different security metrics give different insights to designs, making a comprehensive analysis mandatory. For instance, while eviction-set building was fastest for randomized skewed caches, these caches featured lower eviction entropy and higher practical attack complexity. Our experiments show that all non-partitioned designs allow for effective cryptographic attacks. However, in state-of-the-art secure caches, eviction-based attacks are more difficult to mount than occupancy-based attacks, highlighting the need to consider the latter in cache design.Daniel Genkin, William Kosasih, Fangfei Liu, Anna Trikalinou, Thomas Unterluggauer, Yuval Yaro

Linking-Based Revocation for Group Signatures: A Pragmatic Approach for Efficient Revocation Checks

Group signature schemes (GSS) represent an important privacy-enhancing technology. However, their practical applicability is restricted due to inefficiencies of existing membership revocation mechanisms that often place a too large computational burden and communication overhead on the involved parties. Moreover, it seems that the general belief (or unwritten law) of avoiding online authorities by all means artificially and unnecessarily restricts the efficiency and practicality of revocation mechanisms in GSSs. While a mindset of preventing online authorities might have been appropriate more than 10 years ago, today the availability of highly reliable cloud computing infrastructures could be used to solve open challenges. More specifically, in order to overcome the inefficiencies of existing revocation mechanisms, we propose an alternative approach denoted as linking-based revocation (LBR) which is based on the concept of controllable linkability. The novelty of LBR is its transparency for signers and verifiers that spares additional computations as well as updates. We therefore introduce dedicated revocation authorities (RAs) that can be contacted for efficient (constant time) revocation checks. In order to protect these RAs and to reduce the trust in involved online authorities, we additionally introduce distributed controllable linkability. Using latter, RAs cooperate with multiple authorities to compute the required linking information, thus reducing the required trust. Besides efficiency, an appealing benefit of LBR is its generic applicability to pairing-based GSSs secure in the BSZ model as well as GSSs with controllable linkability. This includes the XSGS scheme, and the GSSs proposed by Hwang et al., one of which has been standardized in the recent ISO 20008-2 standard

Isap v2.0

Contains fulltext : 221033.pdf (publisher's version ) (Open Access

Identification of Hsc70 as target for AGE modification in senescent human fibroblasts

Cellular senescence is known as a potent mechanism of tumor suppression, and cellular senescence in vitro also reflects at least some features of aging in vivo. The Free Radical Theory of aging suggests that reactive oxygen species are important causative agents of aging and cellular senescence. Besides damage of nucleic acids and lipids, also oxidative modifications of proteins have been described as potential causative events in the senescence response. However, the identity of protein targets for post-translational modifications in senescent cells has remained unclear. In the present communication, we analyzed the occurrence of oxidative posttranslational modifications in senescent human endothelial cells and dermal fibroblasts. We found a significant increase in the level of protein carbonyls and AGE modification with senescence in both cell types. Using 2D-Gel electrophoresis and Western Blot we found that heat shock cognate protein 70 is a bona fide target for AGE modification in human fibroblasts

Cytoplasmic location of NR4A1 in aggressive lymphomas is associated with a favourable cancer specific survival

Abstract The nuclear orphan receptor NR4A1 functions as tumour suppressor in aggressive lymphomas by pro-apoptotic genomic and non-genomic effects. Here, we immunohistochemically studied the clinico-pathological relevance of NR4A1 protein expression patterns in a cohort of 60 diffuse large B cell lymphoma (DLBCL) patients and non-neoplastic lymph nodes. We observed a significant association between high cytoplasmic NR4A1 and favourable cancer-specific survival and the germinal centre B cell-like subtype, respectively. Moreover, the percentage of lymphoma cells exhibiting cytoplasmic NR4A1 significantly correlated to those showing cleaved caspase 3. Complementary, functional profiling using gene set enrichment of Reactome pathways based on publicly available microarray data was applied to determine pathways potentially implicated in cytoplasmic localization of NR4A1 and validated by means of semi quantitative real-time PCR. The pathway analysis revealed changes in the ERK1/2 pathway, and this was corroborated by the finding that high cytoplasmic NR4A1 was associated with higher expression of ERK1/2 targets in our cohort. These data indicate that high cytoplasmic NR4A1 is associated with a favourable lymphoma-specific survival and highlights the importance of NR4A1 expression patterns as potential prognostic marker for risk assessment in aggressive lymphomas

Correction: High Keratin 8/18 Ratio Predicts Aggressive Hepatocellular Cancer Phenotype12 (vol 12, pg 256, 2019)

n/